The theoretical setting of hierarchical Bayesian inference is gaining acceptance as a framework for understanding cortical computation. In this paper, we describe how Bayesian belief propagation in a spatio-temporal hierarchical model, called Hierarchical Temporal Memory (HTM), can lead to a mathematical model for cortical circuits. An HTM node is abstracted using a coincidence detector and a mixture of Markov chains. Bayesian belief propagation equations for such an HTM node define a set of functional constraints for a neuronal implementation. Anatomical data provide a contrasting set of organizational constraints. The combination of these two constraints suggests a theoretically derived interpretation for many anatomical and physiological features and predicts several others. ...

Citation: George D, Hawkins J (2009) Towards a Mathematical Theory of Cortical Micro-circuits. PLoS Comput Biol 5(10): e1000532. doi:10.1371/journal.pcbi.1000532

"We use AS3 to take drawing input and send it back to a server running the Numenta software. The server performs and inference and sends a response back to the Flash frontend. To learn more about how HTMs work, go to"